INT284669

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Latest revision as of 19:37, 21 September 2012

Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.58
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (LRRK2) plasma membrane (LRRK2) intracellular (LRRK2)
GTPase activity (LRRK2) cytoplasm (LRRK2)
Anatomy Link Frequency
neuronal 1
dopaminergic neurons 1
LRRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 164 80.72 Quite High
spondylitis 8 75.00 Quite High
psoriasis 16 72.32 Quite High
Crohn's disease 60 66.24 Quite High
Inflammation 36 47.16 Quite Low
Arthritis 8 34.64 Quite Low
rheumatoid arthritis 16 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 144 99.98 Very High Very High Very High
Toxicity 128 99.12 Very High Very High Very High
Helminth Infection 144 98.86 Very High Very High Very High
Disease 232 91.32 High High
Inflammatory Bowel Disease 100 88.08 High High
Ankylosing Spondylitis 168 80.96 Quite High
Diabetes Mellitus 20 76.32 Quite High
Psoriasis 16 72.32 Quite High
Creutzfeldt Jakob Disease 4 69.84 Quite High
Kuru 2 69.36 Quite High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.82 (95% CI:0.74–0.91)), LRRK2/MUC19 (rs11175593, P?
Gene_expression (/) of LRRK2
1) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2996314 Disease Relevance 0.85 Pain Relevance 0.41
0.82 (95% CI:0.74–0.91)), LRRK2/MUC19 (rs11175593, P?
Gene_expression (rs11175593) of LRRK2
2) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2996314 Disease Relevance 0.85 Pain Relevance 0.42
0.83 (95% CI:0.76–0.91)), LRRK2/MUC19 (rs11175593, P?
Gene_expression (/) of LRRK2
3) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.50 Pain Relevance 0.16
0.83 (95% CI:0.76–0.91)), LRRK2/MUC19 (rs11175593, P?
Gene_expression (rs11175593) of LRRK2
4) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.51 Pain Relevance 0.16
However, transgenic LRRK2 expression also led to a preferential loss of dopaminergic neurons, with G2019S fPD LRRK2 being measurably more toxic than wild type LRRK2.
Gene_expression (expression) of LRRK2 in dopaminergic neurons associated with targeted disruption
5) Confidence 0.24 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 0.86 Pain Relevance 0
Saha et al [63] have recently shown that knockdown of lrk-1 sensitizes worms to the mitochondrial toxic rotenone, while pan-neuronal expression of wild type human or G2019S fPD LRRK2 (driven by the snb-1 promoter) protects against rotenone toxicity.
Gene_expression (expression) of LRRK2 in neuronal associated with toxicity and helminth infection
6) Confidence 0.21 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 1.01 Pain Relevance 0

[edit] General Comments

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