INT284857

Context Info Confidence 0.16 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0.17

cell differentiation (Nav1) endoplasmic reticulum (S100a10) cytoskeleton (Nav1) cytoplasm (Nav1)

Anatomy Link Frequency plasma 2 S100a10 (Mus musculus) Nav1 (Mus musculus)

Pain Link Frequency Relevance Heat withdrawal 2 80.76 Pain threshold 1 71.08 nociceptor 1 61.20 sodium channel 11 50.00 tetrodotoxin 13 5.00 Pain 5 5.00 Analgesic 2 5.00 Acute pain 1 5.00 Inflammatory stimuli 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 7 93.84 Pain 7 71.08 Nociception 3 41.96 Inflammatory Pain 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These contradictions may be explained by the significant compensatory upregulation of p11mRNA in DRG of the Pdzd2-deficient mice, as the fact that p11 promotes the functional expression of NaV1.8 into the plasma membrane of sensory neurons.

p11 Positive_regulation (promotes) of Gene_expression (expression) of NaV1 in plasma

1) Confidence 0.16 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0.30 Pain Relevance 0.17

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