INT284870

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn3b) plasma membrane (Scn3b)
Anatomy Link Frequency
ventricles 1
hearts 1
Scn3b (Mus musculus)
Pain Link Frequency Relevance Heat
action potential duration 15 99.98 Very High Very High Very High
Action potential 78 95.84 Very High Very High Very High
addiction 15 5.00 Very Low Very Low Very Low
Eae 9 5.00 Very Low Very Low Very Low
Nav1.1 6 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
Nav1.9 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 9 96.16 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 39 92.48 High High
Syndrome 12 78.64 Quite High
Congenital Anomalies 6 65.32 Quite High
Ventricular Tachycardia 66 50.68 Quite High
Targeted Disruption 18 50.00 Quite Low
Adhesions 6 45.24 Quite Low
Heart Arrhythmia 27 20.64 Low Low
Camurati-engelmann Disease 6 5.00 Very Low Very Low Very Low
Bartter Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we have for the first time associated the lack of the Scn3b gene with a ventricular arrhythmogenesis in intact perfused hearts whose features are similar to those shown in Scn5a+/?
Regulation (lack) of Scn3b in hearts
1) Confidence 0.45 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0 Pain Relevance 0
Secondly, ventricles of such mice showed altered expression levels of Scn3b, Scn1b and Scn5a mRNA.
Regulation (altered) of Scn3b in ventricles
2) Confidence 0.27 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.33 Pain Relevance 0
Endocardial APD values in Scn3b?
Regulation (values) of Scn3b associated with action potential duration
3) Confidence 0.24 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.12 Pain Relevance 0.34

General Comments

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