INT285025

Context Info Confidence 0.11 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.78 Pain Relevance 0.07

mitochondrion (Bnip3, Bak1) nucleoplasm (Bnip3) nuclear envelope (Bnip3) aging (Bak1) endoplasmic reticulum (Bak1) intracellular (Bak1)

Anatomy Link Frequency retina 1 Bnip3 (Rattus norvegicus) Bak1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 32 90.72 Central nervous system 2 5.72 anesthesia 3 5.00 isoflurane 2 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 32 96.92 Death 7 95.52 Stress 3 94.00 Coronary Artery Disease 1 90.72 Hypoxia 1 79.20 Retina Disease 17 53.12 Cv Unclassified Under Development 11 43.44 Ocular Hypertension 8 27.52 Targeted Disruption 2 13.52 Cv General 4 Under Development 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, it would be interesting to study Bnip3-induced activation of Bax and Bak and to analyze whether Bnip-3 could also be associated with the increase in apoptosis observed after I/R in the retina.

Bnip3 Positive_regulation (activation) of Bak in retina associated with apoptosis

1) Confidence 0.11 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.78 Pain Relevance 0.07

General Comments

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