INT285145

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.09
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MGMT) methyltransferase activity (MGMT) nucleus (MGMT)
DNA binding (MGMT)
Anatomy Link Frequency
GBM 2
MGMT (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 42 97.62 Very High Very High Very High
palliative 3 80.00 Quite High
dexamethasone 12 56.88 Quite High
Inflammation 15 47.60 Quite Low
positron emission tomography 6 44.28 Quite Low
addiction 3 21.92 Low Low
headache 9 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 87 99.44 Very High Very High Very High
Apoptosis 9 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 294 98.68 Very High Very High Very High
Cancer 83 83.68 Quite High
Malignant Neoplastic Disease 29 78.64 Quite High
Brain Tumor 54 77.84 Quite High
Stress 6 74.32 Quite High
Recurrence 9 68.24 Quite High
Infection 42 67.04 Quite High
Sprains And Strains 4 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the patient in this study expressed hypermethylation of the MGMT gene promoter, which enhances the therapeutic action of temozolomide and is prognostic for increased survival [26], no prior cases of rapid GBM regression have been reported in patients with the MGMT hypermethylation phenotype to our knowledge.
Positive_regulation (hypermethylation) of MGMT in GBM associated with glioblastoma
1) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2874558 Disease Relevance 0.78 Pain Relevance 0.10
In general, survival is better for younger patients than for older patients and also for those patients with promoter hypermethylation of the O6-methylguanine methyltransferase (MGMT) gene [1,3].
Positive_regulation (hypermethylation) of MGMT
2) Confidence 0.48 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2874558 Disease Relevance 1.29 Pain Relevance 0.08
Based on the MRI and PET-CT data, we speculate that the combined conventional and metabolic approach to GBM management in this patient enhanced early MGMT related cytotoxicity and apoptosis.
Positive_regulation (enhanced) of MGMT in GBM associated with glioblastoma, apoptosis and imagery
3) Confidence 0.41 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2874558 Disease Relevance 0.98 Pain Relevance 0.08
MGMT-mediated increase in marking of a lentiviral anti-HIV vector
Positive_regulation (increase) of MGMT associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.40 Pain Relevance 0
The MGMT protein is expressed in normal human tissues, so in order to enhance selection, a potent inhibitor, O6-benzylguanine (O6BG) is used to inactivate endogenous MGMT.
Positive_regulation (inactivate) of MGMT
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.64 Pain Relevance 0

General Comments

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