INT285424

Context Info Confidence 0.25 First Reported 2007 Last Reported 2007 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.09

signal transduction (TLR1, TLR2) plasma membrane (TLR1, TLR2) intracellular (TLR1, TLR2) cytoplasm (TLR2)

TLR1 (Homo sapiens) TLR2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 9 90.56 Inflammatory response 11 87.44 Inflammation 2 38.28 tolerance 2 5.00 chemokine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 13 87.04 Cadaver 4 5.00 Death 3 5.00 Pseudomonas Infection 2 5.00 Herpes Simplex Virus 2 5.00 Sprains And Strains 1 5.00 Bacterial Respiratory Disease 1 5.00 Congenital Anomalies 1 5.00 Hypersensitivity 1 5.00 Vibrio Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although no distinction was made among the TLR dimers in the report, TLR1/TLR2 heterodimer was most likely responsible for the recognition of the cell wall extract of S. aureus.

Spec (likely) Regulation (responsible) of TLR1 Binding (heterodimer) of TLR2

1) Confidence 0.25 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.09 Pain Relevance 0.09

General Comments

This test has worked.