INT285474

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.15
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fgfr1) nucleus (Fgfr1) kinase activity (Fgfr1)
cytoplasm (Fgfr1)
Anatomy Link Frequency
epidermis 2
connective tissue 2
keratinocytes 2
Fgfr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 69 99.62 Very High Very High Very High
Inflammation 96 89.96 High High
psoriasis 46 70.72 Quite High
chemokine 17 21.84 Low Low
rheumatoid arthritis 88 7.52 Low Low
Inflammatory mediators 6 6.04 Low Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
Arthritis 26 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 32 98.36 Very High Very High Very High
Hypersensitivity 1 96.96 Very High Very High Very High
Congenital Anomalies 21 95.16 Very High Very High Very High
Systemic Sclerosis 34 92.00 High High
INFLAMMATION 103 89.96 High High
Dermatitis 13 80.88 Quite High
Skin Diseases 12 79.84 Quite High
Diffuse Scleroderma 1 74.24 Quite High
Psoriasis 63 70.72 Quite High
Limited Scleroderma 1 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time RT-PCR using RNA from isolated epidermis of control and mutant mice demonstrated a strong reduction of Fgfr1 and Fgfr2 expression (Fig. 1 B) in newborn single and double knockout mice, which further declined until postnatal day 18 (P18; Fig. 1 B and not depicted).
Negative_regulation (reduction) of Gene_expression (expression) of Fgfr1 in epidermis associated with targeted disruption
1) Confidence 0.40 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.26 Pain Relevance 0
Generation and maintenance of mice lacking FGFR1 and/or FGFR2 in keratinocytes
Negative_regulation (lacking) of Neg (lacking) Gene_expression (/) of FGFR1 in keratinocytes
2) Confidence 0.40 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.77 Pain Relevance 0.15
Cytokine or cytokine receptor patterns showed high expression of CCR1, FGFR1, connective tissue growth factor (CTGF), FGF7, and SCYA19 in biopsies from SSC patients.
Negative_regulation (showed) of Gene_expression (expression) of FGFR1 in connective tissue associated with hypersensitivity and cytokine
3) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.12 Pain Relevance 0.10

General Comments

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