INT285546

Context Info Confidence 0.15 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.61 Pain Relevance 0.40

endosome (IL15) aging (IL15) Golgi apparatus (IL15) cell-cell signaling (IL15) cytoplasm (IL15) extracellular space (IL15)

IL15 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 88 97.84 cytokine 53 87.12 Kinase C 1 71.56 Inflammation 44 64.00 antagonist 4 54.56 Arthritis 26 52.80 chemokine 17 51.84 Multiple sclerosis 48 5.00 psoriasis 44 5.00 Adalimumab 9 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 89 97.84 Death 10 72.08 INFLAMMATION 45 64.00 Arthritis 16 52.80 Autoimmune Disease 33 50.00 Disease 69 42.16 Systemic Lupus Erythematosus 65 5.00 Multiple Sclerosis 57 5.00 Psoriasis 49 5.00 Systemic Sclerosis 34 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

High levels of IL-7 and IL-15 mRNA and protein expression have been demonstrated in synovial tissue cells from RA patients [41].

Regulation (levels) of Gene_expression (expression) of IL-15 associated with rheumatoid arthritis

1) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.61 Pain Relevance 0.40

General Comments

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