INT285748

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.01 Pain Relevance 0.31

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL) Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) plasma membrane (C6orf25)

Anatomy Link Frequency B cells 2 PRL (Homo sapiens) C6orf25 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 1 100.00 cytokine 5 93.48 Dopamine 10 79.16 anesthesia 1 72.36 Inflammation 1 56.24 aspirin 4 5.00 Lamotrigine 4 5.00 antagonist 4 5.00 withdrawal 1 5.00 Arthritis 1 5.00

Disease Link Frequency Relevance Heat Rupture 1 100.00 Rheumatic Diseases 2 84.60 Systemic Lupus Erythematosus 51 82.08 Galactorrhea 47 79.68 Injury 2 71.00 Stress 3 69.12 Apoptosis 1 56.84 INFLAMMATION 1 56.24 Disease 9 38.88 Hypophysis Disease 2 30.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This in turn, stimulates activated B cells to proliferate and differentiate supporting the hypothesis that PRL promotes a rupture of tolerance by stimulating increased immunoglobulin G (IgG) production [7].

PRL Positive_regulation (stimulating) of Positive_regulation (increased) of immunoglobulin in B cells associated with rupture and tolerance

1) Confidence 0.01 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 1.01 Pain Relevance 0.31

General Comments

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