INT286289

Context Info Confidence 0.02 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.29 Pain Relevance 0

signal transduction (Emr1) plasma membrane (Emr1) signal transducer activity (Emr1)

Anatomy Link Frequency skin 2 Emr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory response 3 48.64 agonist 1 46.32 antagonist 5 44.48 cytokine 6 5.00 Arthritis 2 5.00 anesthesia 1 5.00 Inflammation 1 5.00 Multiple sclerosis 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Eosinophilia 2 90.04 Rheumatoid Arthritis 9 85.96 Pulmonary Eosinophilia 1 60.76 Disease 9 53.28 Hypersensitivity 21 50.00 INFLAMMATION 4 48.24 Immunization 6 13.28 Asthma 5 5.00 Multiple Sclerosis 3 5.00 Arthritis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It might be explained either by an immunosuppressive effect as postulated by others since retinoic acid seems to down-regulate expression of the cutaneous lymphocyte-associated antigen (CLA), a surface glycoprotein expressed by skin-homing T cells [41].

Negative_regulation (down) of Gene_expression (expression) of surface glycoprotein in skin

1) Confidence 0.02 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.29 Pain Relevance 0

General Comments

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