INT286679

Context Info Confidence 0.42 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.43 Pain Relevance 0.26

mitochondrion (Maob) oxidoreductase activity (Maob)

Maob (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 97.88 addiction 12 82.08 alcohol 2 81.64 Nicotine 4 81.12 monoamine 12 50.00 Serotonin 6 5.00 sSRI 4 5.00 Restless leg syndrome 2 5.00 depression 2 5.00 ischemia 2 5.00

Disease Link Frequency Relevance Heat Nicotine Addiction 342 99.78 INFLAMMATION 2 97.88 Cancer 6 90.44 Lung Cancer 6 86.92 Colon Cancer 2 65.60 Suicidal Behaviour 2 52.16 Atherosclerosis 6 5.00 Hypertension 4 5.00 Obesity 4 5.00 Cardiovascular Disorder Under Development 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The persistence of increased protein concentrations of MAO-B was unexpected, even though some haematological and inflammation characteristics remain modified for several years after quitting smoking [19], [35], [36].

Negative_regulation (persistence) of Positive_regulation (increased) of MAO-B associated with nicotine addiction and inflammation

1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.28 Pain Relevance 0.08

Both S and FS exhibited reduced methylation of the MAOB promoter, leading to a more active transcription of the gene and hence a greater protein concentration of MAO-B.

Negative_regulation (reduced) of Positive_regulation (methylation) of MAOB associated with nicotine addiction

2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.15 Pain Relevance 0.19

General Comments

This test has worked.