INT286798

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.34 Pain Relevance 0.97

extracellular space (Il6st, Cntf) cell differentiation (Cntf) cytosol (Cntf) signal transduction (Il6st) growth (Cntf) nucleus (Cntf)

Il6st (Rattus norvegicus) Cntf (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuropathic pain 18 98.76 cytokine 1 98.00 agonist 7 96.56 Spinal cord 87 81.44 Peripheral nerve injury 1 66.24 Pain 14 55.76 allodynia 22 50.00 glial activation 2 43.08 c fibre 10 32.32 Dorsal column 30 5.00

Disease Link Frequency Relevance Heat Syndrome 9 99.16 Neuropathic Pain 40 98.76 Cicatrix 12 97.52 Leukemia 1 97.16 Spinal Cord Injury 67 81.72 Nervous System Injury 1 66.24 Pain 11 55.76 Injury 134 51.96 Hyperalgesia 12 5.00 Ganglion Cysts 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to its interactions with CNTF, the gp130 protein is a shared receptor for several related cytokines, including leukemia inhibitory factor (LIF) and interleukin-6 (IL-6, which has tertiary structure homology with CNTF) [52].

gp130 Binding (interactions) of CNTF associated with leukemia and cytokine

1) Confidence 0.10 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.34 Pain Relevance 0.97

General Comments

This test has worked.