INT286810

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.03
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cspg4) cell proliferation (Cspg4) plasma membrane (Cspg4)
intracellular (Cspg4) signal transducer activity (Cspg4)
Anatomy Link Frequency
hippocampus 2
band 1
soma 1
Cspg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 29 99.32 Very High Very High Very High
imagery 26 95.12 Very High Very High Very High
Action potential 13 91.32 High High
PcTx1 8 90.72 High High
ischemia 32 84.88 Quite High
gABA 12 84.08 Quite High
ASIC 228 71.20 Quite High
GABAergic 12 67.84 Quite High
Multiple sclerosis 4 61.20 Quite High
Angina 4 60.32 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 8 92.48 High High
Cv Unclassified Under Development 24 84.88 Quite High
Epilepsy 16 64.48 Quite High
Cv General 3 Under Development 4 60.32 Quite High
Acidosis 12 59.04 Quite High
Brain Injury 4 55.20 Quite High
Convulsion 12 53.48 Quite High
Brain Hemorrhage 4 52.96 Quite High
Neurological Disease 8 51.96 Quite High
Neuropathic Pain 40 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That inhibiting desensitization of AMPA receptors increases [Ca2+]i elevations may indicate that under control conditions the [Ca2+]i elevations due to synaptic NG2+ AMPA receptor activation may be localized and thus not detectable in our experiments, but when amplified enable their detection by invading the soma.
Localization (localized) of NG2 in soma
1) Confidence 0.60 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2909395 Disease Relevance 0 Pain Relevance 0.06
Expression levels of phosphacan (320–340 kDa band) and NG2 (270–300 kDa band), respectively, were normalized for each sample to ?
Localization (normalized) of NG2 in band
2) Confidence 0.29 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0 Pain Relevance 0
A magnified image of an NG2 cell in the stratum radiatum (Fig. 6D) showed that ASIC1a (Fig. 6E) and NG2 were co-localized (Fig. 6F).
Localization (localized) of NG2
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.25
Finally, immunocytochemistry showed co-localization of ASIC1a and NG2 proteins in the hippocampus.
Localization (localization) of NG2 in hippocampus associated with hippocampus
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937019 Disease Relevance 0.21 Pain Relevance 0.32
Finally, immunocytochemistry showed co-localization of ASIC1a and NG2 proteins in the hippocampus.
Localization (-) of NG2 in hippocampus associated with hippocampus
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937019 Disease Relevance 0.21 Pain Relevance 0.32
NG2 cells proliferate and/or release a variety of neuroprotective factors in response to pathological changes [3], [14], [45].
Localization (release) of NG2
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0.60 Pain Relevance 0.37

General Comments

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