INT287095

Context Info Confidence 0.24 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.47 Pain Relevance 0.41

nucleus (T) DNA binding (T) cytoplasm (T)

Anatomy Link Frequency neurons 2 T (Mus musculus)

Pain Link Frequency Relevance Heat induced neuropathy 1 91.28 intrathecal 2 89.68 Pain 9 80.80 Dorsal horn 4 72.52 Lasting pain 2 49.84 qutenza 10 24.44 Inflammation 11 23.20 spinal dorsal horn 5 7.84 withdrawal 5 5.00 Neuropathic pain 4 5.00

Disease Link Frequency Relevance Heat Neuropathic Pain 7 90.64 Hypersensitivity 14 80.96 Pain 11 80.80 Nociception 13 26.56 INFLAMMATION 12 23.20 Sprains And Strains 1 19.08 Targeted Disruption 6 5.00 Hyperalgesia 3 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Ganglion Cysts 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have shown that neurons from a mouse model of neurodegeneration over-express trkB.T1, resulting in a significant increase in resting intracellular calcium; reducing trkB.T1 expression in those neurons reduced intracellular calcium to wildtype levels [23].

Negative_regulation (reducing) of Gene_expression (expression) of T1 in neurons

1) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.47 Pain Relevance 0.41

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