INT287203

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.08
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
testes 4
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 2 67.24 Quite High
Hippocampus 8 32.48 Quite Low
Neurotransmitter 5 29.04 Quite Low
monoamine 1 25.36 Quite Low
Serotonin 1 24.16 Low Low
Clonidine 15 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 392 100.00 Very High Very High Very High
Toxicity 16 99.12 Very High Very High Very High
Body Weight 7 98.32 Very High Very High Very High
Frontotemporal Dementia 3 95.72 Very High Very High Very High
Targeted Disruption 133 95.20 Very High Very High Very High
Death 28 94.40 High High
Parkinson's Disease 9 94.28 High High
Spinocerebellar Ataxia Type 2 6 92.44 High High
Obesity 14 91.76 High High
Hypertension 8 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings indicate that neither HD pathogenesis, nor DNA repair gene expression levels is a major determinant of the tissue specificity of somatic instability.
Negative_regulation (determinant) of Gene_expression (expression) of HD associated with disease
1) Confidence 0.37 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0.10 Pain Relevance 0
This could arise through a decrease in the production of gonadotrophin-releasing hormone in the hypothalamus [56], a loss of the direct neuronal hypothalamic-testicular pathway [54] or the direct effect of mutant Htt in the testes [55].
Negative_regulation (loss) of Gene_expression (production) of Htt in testes
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 1.16 Pain Relevance 0.03
This could arise through a decrease in the production of gonadotrophin-releasing hormone in the hypothalamus [56], a loss of the direct neuronal hypothalamic-testicular pathway [54] or the direct effect of mutant Htt in the testes [55].
Negative_regulation (decrease) of Gene_expression (production) of Htt in testes
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778556 Disease Relevance 1.17 Pain Relevance 0.03
Meanwhile, mutant Htt expression did not suppress activities of other kinases such as Cdk1/Cdc2 or MAPK/extracellular-regulated kinase (ERK; Fig. 5 F), supporting the view that the effect of mutant Htt on DNA–PK could be specific to some extent.
Neg (not) Negative_regulation (suppress) of Gene_expression (expression) of mutant Htt
4) Confidence 0.34 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.06 Pain Relevance 0
Rilmenidine decreases levels of mutant huntingtin
Negative_regulation (decreases) of Gene_expression (levels) of mutant huntingtin
5) Confidence 0.19 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 1.14 Pain Relevance 0
Rilmenidine administration attenuated the signs of disease in a HD mouse model and reduced levels of the mutant huntingtin fragment.
Negative_regulation (reduced) of Gene_expression (fragment) of mutant huntingtin associated with disease
6) Confidence 0.19 Published 2010 Journal Human Molecular Genetics Section Abstract Doc Link PMC2865373 Disease Relevance 0.72 Pain Relevance 0
CCI-779, a rapamycin ester (i.e., an analogue of rapamycin) reduces both mutant huntingtin and ataxin-3 levels, thereby attenuating toxicity in mouse models of HD and SCA3, respectively [68,69].
Negative_regulation (reduces) of Gene_expression (levels) of huntingtin associated with toxicity
7) Confidence 0.04 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.73 Pain Relevance 0

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