INT287309

Context Info Confidence 0.59 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 5.67 Pain Relevance 1.52

small molecule metabolic process (ENO1) lyase activity (ENO1) carbohydrate metabolic process (ENO1) DNA binding (ENO1) cytoplasm (ENO1) cytosol (ENO1)

Anatomy Link Frequency skin 1 ENO1 (Homo sapiens)

Pain Link Frequency Relevance Heat Piles 460 100.00 cva 58 100.00 Bile 4 95.56 Biofeedback 8 80.08 Prostatitis 4 65.12 Inflammation 12 53.36 Pain 66 22.44 Lasting pain 36 5.00 Osteoarthritis 27 5.00 Perioperative pain 12 5.00

Disease Link Frequency Relevance Heat Anorectal Disorders 460 100.00 Cv General 3 Under Development 54 100.00 Incontinence 44 99.90 Injury 33 99.52 Shock 1 99.46 Sepsis 72 99.40 Emergencies 4 98.58 Hemorrhage 134 98.18 Flatulence 12 94.56 Frailty 4 90.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Two heterosexual patients had severe penile trauma with wide excision of penile skin and dramatic bleeding requiring emergency hospitalization after active anal intercourse with companions who had undergone PPH.

Positive_regulation (undergone) of PPH in skin associated with emergencies, injury, piles and hemorrhage

1) Confidence 0.59 Published 2008 Journal Tech Coloproctol Section Body Doc Link PMC2778725 Disease Relevance 1.61 Pain Relevance 0.33

Nevertheless, the gravity of these adverse events seems to be greater after PPH, since pelvic sepsis frequently requires a stoma while this is very rare after manual procedure [103].

Positive_regulation (greater) of PPH associated with piles and sepsis

2) Confidence 0.43 Published 2008 Journal Tech Coloproctol Section Body Doc Link PMC2778725 Disease Relevance 0.84 Pain Relevance 0.21

Postpartum haemorrhage (PPH) is a significant and increasing contributor to maternal mortality and morbidity.

Positive_regulation (increasing) of PPH associated with cva

3) Confidence 0.41 Published 2010 Journal Int Breastfeed J Section Abstract Doc Link PMC2889881 Disease Relevance 0.55 Pain Relevance 0.25

It is a matter of fact that incontinence may follow PPH, even if it is not frequent [17, 20].

Spec (may) Positive_regulation (follow) of PPH associated with incontinence and piles

4) Confidence 0.40 Published 2008 Journal Tech Coloproctol Section Body Doc Link PMC2778725 Disease Relevance 1.23 Pain Relevance 0.38

Tenesmus affected 50% of the patients who underwent PPH for fourth-degree hemorrhoids one year after surgery in a prospective randomized trial that compared stapled hemorrhoidopexy with manual hemorrhoidectomy [19].

Positive_regulation (underwent) of PPH associated with piles

5) Confidence 0.40 Published 2008 Journal Tech Coloproctol Section Body Doc Link PMC2778725 Disease Relevance 1.35 Pain Relevance 0.36

Interestingly, some of these proteins, such as heat shock protein beta-1 (HSPB1) or alpha enolase (ENOA) were present in more than one spot, indicating that they undergo posttranslational modifications, such as glycosylation or phosphorylation.

Positive_regulation (present) of alpha enolase associated with shock

6) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.10 Pain Relevance 0

General Comments

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