INT287480

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIB, TBK1) cytoplasm (NFKBIB, TBK1) signal transduction (NFKBIB)
plasma membrane (TBK1) nucleus (NFKBIB) signal transducer activity (NFKBIB)
Anatomy Link Frequency
nucleus 2
NFKBIB (Homo sapiens)
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 10 51.00 Quite High
cytokine 5 48.08 Quite Low
peripheral neuropathy 12 13.12 Low Low
dexamethasone 46 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 46 96.40 Very High Very High Very High
Apoptosis 8 94.56 High High
Adhesions 5 93.00 High High
Thrombosis 11 51.00 Quite High
Osteoporosis 2 30.00 Quite Low
Recurrence 4 29.60 Quite Low
Hypercalcemia 2 28.96 Quite Low
Peripheral Neuropathy 12 13.12 Low Low
Cv General 3 Under Development 5 11.88 Low Low
Thrombocytopenia 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Degradation of IkB by proteasome activates NF-kB, which moves to the nucleus and up-regulates transcription of proteins that promote cell survival and growth, reduce susceptibility to apoptosis, influence the expression of adhesion molecules and induce drug resistance in myeloma cells.
Protein_catabolism (Degradation) of IkB in nucleus Positive_regulation (activates) of NF-kB associated with apoptosis and adhesions
1) Confidence 0.01 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 0.60 Pain Relevance 0.03

General Comments

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