INT287890

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.87 Pain Relevance 0.14

plasma membrane (EPHB2) nucleus (THEMIS) cytoplasm (THEMIS)

THEMIS (Homo sapiens) EPHB2 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 6 99.04 Inflammation 2 74.04 cINOD 13 5.00 aspirin 7 5.00 antagonist 7 5.00 agonist 2 5.00 Arthritis 2 5.00 withdrawal 1 5.00 vincristine 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Cancer 81 91.00 Metastasis 4 90.04 Disease 18 78.04 INFLAMMATION 2 74.04 Affective Disorder 1 73.48 Diabetes Mellitus 2 72.00 Leukemia 2 32.40 Colon Cancer 10 6.32 Adenoma 2 5.52 Colorectal Cancer 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Several mechanisms of action might be relevant for the biological activity of VPA: (1) VPA increases the DNA binding ability of activating protein-1 (AP-1) transcription factor, and the expression of genes regulated by the extracellular-regulated kinase (ERK)-AP-1 pathway; (2) VPA downregulates protein kinase C (PKC) activity; (3) VPA inhibits GSK3?

pathway Regulation (regulated) of Gene_expression (expression) of ERK associated with kinase c

1) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.87 Pain Relevance 0.14

General Comments

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