INT287926

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.59 Pain Relevance 0.06

nucleus (THEMIS) cytoplasm (THEMIS)

THEMIS (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 14 64.20 cINOD 26 5.00 aspirin 14 5.00 Kinase C 12 5.00 Inflammation 4 5.00 agonist 4 5.00 Arthritis 4 5.00 withdrawal 2 5.00 vincristine 2 5.00 metalloproteinase 2 5.00

Disease Link Frequency Relevance Heat Cancer 162 96.00 Apoptosis 36 90.44 Colon Cancer 20 43.84 Cardiovascular Disease 2 26.08 Colorectal Cancer 36 5.00 Disease 36 5.00 Rheumatoid Arthritis 16 5.00 Familial Adenomatous Polyposis 14 5.00 Skin Cancer 10 5.00 Polyps 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of the entire Wnt signaling pathway, least is known about the ligand-receptor interaction.

pathway Binding (interaction) of

1) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.77 Pain Relevance 0.03

Although ligand-receptor interactions are heavily targeted in drug discovery, the ligand-receptor interaction in the Wnt signaling pathway is not as straightforward as for other pathways.

pathway Binding (interaction) of

2) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.82 Pain Relevance 0.03

General Comments

This test has worked.