INT287929

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.44
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (THEMIS) cytoplasm (THEMIS)
THEMIS (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 24 98.12 Very High Very High Very High
antagonist 28 96.88 Very High Very High Very High
Inflammation 8 66.92 Quite High
vincristine 4 50.24 Quite High
cINOD 52 5.00 Very Low Very Low Very Low
aspirin 28 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 20 99.92 Very High Very High Very High
Breast Cancer 16 95.36 Very High Very High Very High
Cancer 324 95.28 Very High Very High Very High
Targeted Disruption 8 86.76 High High
Colon Cancer 40 84.24 Quite High
Metastasis 16 82.92 Quite High
Disease 72 70.92 Quite High
INFLAMMATION 8 66.92 Quite High
Affective Disorder 4 66.36 Quite High
Diabetes Mellitus 8 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3Lead structures for Wnt signaling pathway inhibitors.
Negative_regulation (inhibitors) of pathway
1) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0.10
-catenin signaling activity, and inhibition of this signaling pathway by Gleevec may be further explored as an important target for alternative/adjuvant treatments for different types of cancer.
Negative_regulation (inhibition) of pathway associated with cancer
2) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.48 Pain Relevance 0
, a negative regulator of the Wnt signaling pathway; (4) VPA activates the peroxisome proliferator-activated receptors PPAR?
Negative_regulation (regulator) of pathway
3) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.80 Pain Relevance 0.13
Blocking this pathway using antibodies to Fzd5, a receptor for Wnt5a, was shown to inhibit PKC activity and cellular invasion.
Negative_regulation (Blocking) of pathway associated with kinase c
4) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.16 Pain Relevance 0.07

General Comments

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