INT287929

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 2.44 Pain Relevance 0.30

nucleus (THEMIS) cytoplasm (THEMIS)

THEMIS (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 24 98.12 antagonist 28 96.88 Inflammation 8 66.92 vincristine 4 50.24 cINOD 52 5.00 aspirin 28 5.00 agonist 8 5.00 Arthritis 8 5.00 withdrawal 4 5.00 metalloproteinase 4 5.00

Disease Link Frequency Relevance Heat Skin Cancer 20 99.92 Breast Cancer 16 95.36 Cancer 324 95.28 Targeted Disruption 8 86.76 Colon Cancer 40 84.24 Metastasis 16 82.92 Disease 72 70.92 INFLAMMATION 8 66.92 Affective Disorder 4 66.36 Diabetes Mellitus 8 64.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Figure 3Lead structures for Wnt signaling pathway inhibitors.

Negative_regulation (inhibitors) of pathway

1) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0.10

-catenin signaling activity, and inhibition of this signaling pathway by Gleevec may be further explored as an important target for alternative/adjuvant treatments for different types of cancer.

Negative_regulation (inhibition) of pathway associated with cancer

2) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.48 Pain Relevance 0

, a negative regulator of the Wnt signaling pathway; (4) VPA activates the peroxisome proliferator-activated receptors PPAR?

Negative_regulation (regulator) of pathway

3) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.80 Pain Relevance 0.13

Blocking this pathway using antibodies to Fzd5, a receptor for Wnt5a, was shown to inhibit PKC activity and cellular invasion.

Negative_regulation (Blocking) of pathway associated with kinase c

4) Confidence 0.01 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.16 Pain Relevance 0.07

General Comments

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