INT287945

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.70 Pain Relevance 0.05

nucleus (THEMIS) cytoplasm (THEMIS)

THEMIS (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 21 96.96 metalloproteinase 3 31.16 Inflammation 6 21.44 cINOD 39 13.04 aspirin 21 11.76 Kinase C 18 5.00 agonist 6 5.00 Arthritis 6 5.00 withdrawal 3 5.00 vincristine 3 5.00

Disease Link Frequency Relevance Heat Cancer 243 99.12 Disease 54 97.72 Apoptosis 54 95.12 Solid Tumor 3 94.32 Colon Cancer 30 94.08 Adenoma 6 87.20 Repression 3 58.32 Carcinoma 6 31.36 Diabetes Mellitus 6 25.20 Affective Disorder 3 22.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Only Lithium and Valproic acid are discussed here because many studies have demonstrated their effect on the Wnt signaling pathway.

Regulation (effect) of pathway

1) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.33 Pain Relevance 0

-catenin pathway, but most likely indirectly through upregulation of c-Myc which is a target gene of the Wnt pathway.

Regulation (target) of pathway

2) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.59 Pain Relevance 0

Many different types of cancer, in different tissues, have been linked to alterations in the Wnt signaling pathway and it is thus not surprising that oncology is the main disease area where antagonists of this pathway could be of use.

Regulation (alterations) of pathway associated with cancer, antagonist and disease

3) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.78 Pain Relevance 0.05

General Comments

This test has worked.