INT287945

From wiki-pain
Revision as of 07:07, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.70
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (THEMIS) cytoplasm (THEMIS)
THEMIS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 21 96.96 Very High Very High Very High
metalloproteinase 3 31.16 Quite Low
Inflammation 6 21.44 Low Low
cINOD 39 13.04 Low Low
aspirin 21 11.76 Low Low
Kinase C 18 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
vincristine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 243 99.12 Very High Very High Very High
Disease 54 97.72 Very High Very High Very High
Apoptosis 54 95.12 Very High Very High Very High
Solid Tumor 3 94.32 High High
Colon Cancer 30 94.08 High High
Adenoma 6 87.20 High High
Repression 3 58.32 Quite High
Carcinoma 6 31.36 Quite Low
Diabetes Mellitus 6 25.20 Quite Low
Affective Disorder 3 22.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only Lithium and Valproic acid are discussed here because many studies have demonstrated their effect on the Wnt signaling pathway.
Regulation (effect) of pathway
1) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.33 Pain Relevance 0
-catenin pathway, but most likely indirectly through upregulation of c-Myc which is a target gene of the Wnt pathway.
Regulation (target) of pathway
2) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.59 Pain Relevance 0
Many different types of cancer, in different tissues, have been linked to alterations in the Wnt signaling pathway and it is thus not surprising that oncology is the main disease area where antagonists of this pathway could be of use.


Regulation (alterations) of pathway associated with cancer, antagonist and disease
3) Confidence 0.00 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.78 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox