INT288079

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 1 72.72 Quite High
imagery 3 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 34 98.98 Very High Very High Very High
Lifespan 1 95.44 Very High Very High Very High
Dysphagia 2 86.36 High High
Dystonia 2 75.88 Quite High
Tremor 2 75.36 Quite High
Sleep Disorders 2 73.80 Quite High
Convulsion 2 72.04 Quite High
Gauchers Disease 9 32.56 Quite Low
Neurologic Manifestations 13 16.68 Low Low
Hepatotoxicity 2 9.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include neurosteroids and cholesterol-binding agents, which have been shown to delay the progression of disease in animal models of NP-C.23–25 Direct or indirect overexpression of the GTPase, Rab 9, has been shown to reverse the NP-C phenotype in tissue culture26,27 and reduce stored lipids and prolong lifespan in a mouse model of NP-C.28 Recently, curcumin has been suggested to have beneficial effects on intracellular calcium homeostasis and lipid metabolism in NPC1-mutant mice.29 However, data from clinical studies are required to assess the possible role of these compounds in NP-C therapy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GTPase associated with lifespan and disease
1) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781062 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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