INT288232

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.77
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TYMS) mitochondrion (TYMS) small molecule metabolic process (TYMS)
aging (TYMS) cytoplasm (TYMS) cytosol (TYMS)
TYMS (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 1 79.04 Quite High
chemokine 4 48.32 Quite Low
COX2 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 49 99.60 Very High Very High Very High
Mesothelioma 47 99.04 Very High Very High Very High
Apoptosis 4 88.56 High High
Toxicity 7 88.16 High High
Leukemia 1 82.76 Quite High
Stress 1 81.00 Quite High
Disease 20 72.16 Quite High
Colon Cancer 62 64.68 Quite High
Metastasis 8 62.08 Quite High
Recurrence 10 58.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, the novel antifolate pralatrexate demonstrated activity in preclinical models, but not in a phase II trial in mesothelioma patients [16].The only FDA-approved agent for mesothelioma is pemetrexed, an antifolate which principally targets thymidylate synthase, as well as dihydrofolate reductase and glycinamide ribonucleotide formyltransferase.
thymidylate synthase Binding (targets) of associated with mesothelioma
1) Confidence 0.11 Published 2008 Journal Curr Treat Options Oncol Section Body Doc Link PMC2782121 Disease Relevance 1.19 Pain Relevance 0.04
TYMS is located at 18p11.32, and is a target for the anti-cancer drug 5-fluorouracil (5-FU).
TYMS Binding (target) of associated with cancer
2) Confidence 0.07 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.58 Pain Relevance 0

General Comments

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