INT288384

Context Info Confidence 0.15 First Reported 2009 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.04 Pain Relevance 0.22

extracellular space (CHIT1) extracellular region (CHIT1) carbohydrate metabolic process (CHIT1) lysosome (CHIT1)

Anatomy Link Frequency plasma 1 platelet 1 CHIT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Analgesic 2 94.68 Pain 11 89.48 imagery 8 69.44 Inflammatory response 2 5.16 Inflammation 11 5.00 cytokine 10 5.00 Inflammatory stimuli 4 5.00 tolerance 3 5.00 Central nervous system 2 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Infection 21 100.00 Gauchers Disease 60 96.12 Pain 8 89.48 Lymphatic Filariasis 25 89.00 Disease 24 88.24 Compression Fractures 6 86.20 Hydrocele 28 83.04 Necrosis 18 82.92 Lymphedema 49 82.68 Filariasis 6 82.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chitotriosidase activity in plasma samples was determined using the fluorescent substrate 4-methyl umbeliferyl ?

Chitotriosidase Binding (activity) of in plasma

1) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.50 Pain Relevance 0.22

Interestingly, no association of susceptibility to infection with CHIT1 was found in Papua New Guinea (74), demonstrating the importance of genotyping populations from different endemic areas.

CHIT1 Neg (no) Binding (association) of associated with infection

2) Confidence 0.14 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2784903 Disease Relevance 1.37 Pain Relevance 0

For patients given full-dose ERT, platelet counts increased slightly faster, ferritin and TRAP decreased faster, but chitotriosidase and ACE declined more slowly.

chitotriosidase Binding (declined) of in platelet

3) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.18 Pain Relevance 0

General Comments

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