INT288486

Context Info Confidence 0.29 First Reported 2009 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.76 Pain Relevance 0.76

Anatomy Link Frequency colon 2 Tlr8 (Rattus norvegicus)

Pain Link Frequency Relevance Heat spastic colon 127 99.02 Crohn's disease 1 90.76 Inflammation 46 88.52 nud 9 74.00 cytokine 33 50.00 chemokine 6 5.00 abdominal pain 4 5.00 Catecholamine 3 5.00 Pain 3 5.00 Visceral pain 2 5.00

Disease Link Frequency Relevance Heat Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 126 99.02 Disease 1 90.76 Inflammatory Bowel Disease 9 90.00 INFLAMMATION 47 88.52 Sprains And Strains 12 83.20 Stress 60 79.92 Genetic Predisposition To Disease 18 79.84 Dyspepsia 9 74.00 Congenital Anomalies 8 66.24 Gastroenteritis 4 19.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, Brint et al,81 reported a 5-fold up-regulation of TLR4 in women with IBS compared to healthy controls, while reporting a reduced expression of TLR7 and TLR8 in the same patients.

Negative_regulation (reduced) of Gene_expression (expression) of TLR8 associated with spastic colon

1) Confidence 0.29 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.54 Pain Relevance 0.72

While TLR8 was significantly increased in the proximal but not the distal colon (p?

Negative_regulation (While) of Neg (not) Gene_expression (was) of TLR8 in colon

2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.59 Pain Relevance 0.04

General Comments

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