INT28857

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Context Info
Confidence 0.30
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 8.46
Pain Relevance 10.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
PAG 4
midbrain 4
SCT 3
spinal 2
lateral 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 61 100.00 Very High Very High Very High
midbrain 14 100.00 Very High Very High Very High
Raphe magnus 9 100.00 Very High Very High Very High
Antinociceptive 8 100.00 Very High Very High Very High
Periaqueductal grey 5 100.00 Very High Very High Very High
qutenza 3 100.00 Very High Very High Very High
analgesia 2 100.00 Very High Very High Very High
Morphine 24 99.84 Very High Very High Very High
bradykinin 2 99.48 Very High Very High Very High
narcan 14 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 88 100.00 Very High Very High Very High
Bradycardia 10 100.00 Very High Very High Very High
Diabetes Mellitus 10 99.84 Very High Very High Very High
Peripheral Arterial Disease 1 99.44 Very High Very High Very High
Stress 6 98.08 Very High Very High Very High
Body Weight 1 94.60 High High
Nociception 11 94.44 High High
Hyperalgesia 5 82.48 Quite High
Pain 1 62.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition was exclusively of central origin because inhibition of BVB by stimulation of the PAG was unchanged after transection of the spinal cord at the C1 level.
Negative_regulation (inhibition) of Positive_regulation (stimulation) of PAG in PAG associated with urological neuroanatomy, bradycardia and spinal cord
1) Confidence 0.30 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 7907131 Disease Relevance 1.22 Pain Relevance 0.33
Electrical stimulation of the PAG or midbrain RF similarly decreased spontaneous and evoked cell activity.
Negative_regulation (decreased) of Positive_regulation (stimulation) of PAG in midbrain associated with midbrain and central grey
2) Confidence 0.27 Published 1989 Journal Brain Res. Section Abstract Doc Link 2804627 Disease Relevance 0.56 Pain Relevance 0.91
Following electrical stimulation of either the ventral PAG or the NRD, responses to SPL input were inhibited in all NS and WDR units tested.
Negative_regulation (inhibited) of Positive_regulation (stimulation) of PAG in ventral associated with wide dynamic range and central grey
3) Confidence 0.23 Published 1995 Journal Jpn. J. Physiol. Section Abstract Doc Link 8676571 Disease Relevance 0.98 Pain Relevance 0.60
The GSR was inhibited by electrical stimulation of the PAG/NRD.
Negative_regulation (inhibited) of Positive_regulation (stimulation) of PAG associated with central grey
4) Confidence 0.17 Published 1986 Journal Brain Res. Section Abstract Doc Link 3697757 Disease Relevance 0.79 Pain Relevance 0.61
This was supported by the fact that the same treatment with okadaic acid blocked the increase in phosphatase activity in PAG of morphine tolerant mice indicating that selective inhibition of PP2A contributes to enhanced levels of morphine tolerance.
Negative_regulation (blocked) of Positive_regulation (increase) of PAG in PAG associated with tolerance, urological neuroanatomy and morphine
5) Confidence 0.16 Published 2007 Journal Brain Res. Section Abstract Doc Link 17582387 Disease Relevance 0.25 Pain Relevance 1.38
Similarly, intra-spinal application of strychnine or bicuculline resulted in a significant reduction in the PAG stimulation-induced inhibition of responses of STT cells to cutaneous stimuli.
Negative_regulation (reduction) of Positive_regulation (stimulation-induced) of PAG in spinal associated with spinothalamic tract and central grey
6) Confidence 0.08 Published 1994 Journal Brain Res. Section Abstract Doc Link 7987678 Disease Relevance 0.48 Pain Relevance 1.04
Firstly, the gradual loss of analgesia upon recurrent stimulation of the midbrain PAG does not reflect a generalized debilitation or stress and neither a conditioning phenomenon nor a depletion of pools of endogenous opioid peptides.
Negative_regulation (loss) of Positive_regulation (stimulation) of PAG in midbrain associated with stress, periaqueductal grey, endogenous opioid, midbrain and analgesia
7) Confidence 0.05 Published 1987 Journal Brain Res. Section Abstract Doc Link 3427472 Disease Relevance 0.92 Pain Relevance 1.35
A critical level of morphine-induced activation of the rostral lateral PAG is required to inhibit maternal behavior in lactating rats.
Negative_regulation (inhibit) of Positive_regulation (activation) of PAG in lateral associated with central grey and morphine
8) Confidence 0.04 Published 2007 Journal Peptides Section Abstract Doc Link 17194502 Disease Relevance 0.63 Pain Relevance 1.16
Our results showed an attenuation of capsaicin antinociceptive effect (P<0.05) and TRPV1 receptor expression (P=0.023) but an increase in WIN antinociceptive effect (P<0.05) and CB1 receptor expression (P<0.001) in PAG of diabetic vs. non-diabetic rats.
Negative_regulation (attenuation) of Positive_regulation (increase) of PAG associated with qutenza, diabetes mellitus, central grey and antinociceptive
9) Confidence 0.02 Published 2010 Journal Brain Res. Section Abstract Doc Link 20211611 Disease Relevance 2.09 Pain Relevance 1.60
Conditioning stimulation of NRM, NRPG, PAG, CP, SCT and DMH strongly inhibited component 2.
Negative_regulation (inhibited) of Positive_regulation (stimulation) of PAG in SCT associated with raphe magnus and urological neuroanatomy
10) Confidence 0.02 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3795618 Disease Relevance 0.27 Pain Relevance 0.61
Conditioning stimulation of NRM, NRPG, PAG, CP, SCT and DMH strongly inhibited component 2.
Negative_regulation (inhibited) of in PAG Positive_regulation (stimulation) of PAG in SCT associated with raphe magnus and urological neuroanatomy
11) Confidence 0.01 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3795618 Disease Relevance 0.27 Pain Relevance 0.61

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