INT288642

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Snca) mitochondrion (Snca) histone binding (Snca)
plasma membrane (Snca) cytoskeleton (Snca) nucleus (Snca)
Anatomy Link Frequency
striatum 2
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 4 90.16 High High
Dopamine 3 86.52 High High
Hippocampus 1 25.12 Quite Low
Bioavailability 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 13 99.36 Very High Very High Very High
Disease 53 94.96 High High
Targeted Disruption 10 94.64 High High
Neurodegenerative Disease 24 83.12 Quite High
Motor Neuron Diseases 13 68.56 Quite High
Weight Loss 3 65.16 Quite High
Stress 7 63.92 Quite High
Frailty 5 53.68 Quite High
Alzheimer's Dementia 18 47.52 Quite Low
Amnesia 1 7.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the combination treatment resulted in a significant reduction of lipid peroxidation and alpha-synuclein accumulation in the SNpc in MPTP-treated mice, and reduction of lipid peroxidation and DNA oxidative damage in the striatum in the 3-NP rat model.72
Negative_regulation (reduction) of Positive_regulation (accumulation) of alpha-synuclein in striatum associated with parkinson's disease
1) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.93 Pain Relevance 0.09

General Comments

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