INT288644

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.37
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pdss2) cytoplasm (Pdss2)
Pdss2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 89.60 High High
Inflammation 8 78.96 Quite High
Analgesic 20 76.04 Quite High
Central nervous system 2 62.76 Quite High
cerebral cortex 3 53.88 Quite High
Bioavailability 17 50.00 Quite Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 89.60 High High
Mitochondrial Encephalomyopathies 1 89.24 High High
Pressure And Volume Under Development 4 86.60 High High
Infantile Spasms 1 81.12 Quite High
Muscle Hypotonia 1 80.28 Quite High
Renal Disease 1 75.92 Quite High
Encephalopathy 2 75.28 Quite High
Disease 53 74.28 Quite High
Ataxia 19 72.88 Quite High
Frailty 5 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nine genes are presumed to be involved in CoQ10 biosynthesis, and as of now, mutations in three genes have been shown to result in primary CoQ10 deficiency: PDSS1, PDSS2, and COQ2.21 Duncan and colleagues found an autosomal recessive form of neonatal-onset primary coenzyme Q10 deficiency resulting from a nonsense mutation in COQ9.24
PDSS2 Binding (found) of
1) Confidence 0.25 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 0.95 Pain Relevance 0.06
KD2 complex also showed a significant difference from pure drug at 2 h, 3 h and 4 h time interval.
KD2 Binding (complex) of
2) Confidence 0.01 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3002823 Disease Relevance 0.41 Pain Relevance 0.49

General Comments

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