INT288669

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.35
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD83) plasma membrane (CD83)
Anatomy Link Frequency
CD86 2
DCs 2
CD83 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 11 94.08 High High
imagery 45 85.80 High High
pruritus 1 59.56 Quite High
cytokine 15 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 1 100.00 Very High Very High Very High
Cold Sores 203 99.84 Very High Very High Very High
Glioma 34 95.76 Very High Very High Very High
Necrosis 5 88.52 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 44 82.32 Quite High
Infection 92 77.20 Quite High
Radiation Sickness 28 75.00 Quite High
Cancer 87 62.48 Quite High
Photosensitivity Disorders 9 60.96 Quite High
Pruritus 1 59.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During these processes DCs undergo diverse phenotypical and functional changes such as reduced phagocytic ability, upregulated cell surface expression of co-stimulatory molecules and adhesion proteins, such as CD86, CD83, CD54, CD40, and MHC II antigens.
Negative_regulation (reduced) of Gene_expression (expression) of CD83 in CD86 associated with adhesions
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.34 Pain Relevance 0.08
Reduced CD83 expression by HSV-2-exposed DCs has been associated with lessened immunostimulatory function [16], [55], [56], but CD83 was not monitored in our study.
Negative_regulation (Reduced) of Gene_expression (expression) of CD83 associated with cold sores
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 1.07 Pain Relevance 0
Phenotypical expression of the generated DCs were analyzed to determine the expression level of CD14, CD86, CD83 and HLA-DR.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of CD83 in DCs
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2829084 Disease Relevance 0.95 Pain Relevance 0.11

General Comments

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