INT289202

Context Info Confidence 0.23 First Reported 2009 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 1.21 Pain Relevance 1.49

cytosol (TRIO) intracellular (TRIO) cytoplasm (TRIO)

Anatomy Link Frequency Head 1 cortex 1 TRIO (Homo sapiens)

Pain Link Frequency Relevance Heat Transcranial magnetic stimulation 548 99.44 anesthesia 32 84.56 imagery 21 74.40 Pain 6 73.28 positron emission tomography 3 72.44 magnetoencephalography 3 70.72 primary somatosensory cortex 2 68.72 Thalamus 10 66.68 isoflurane 4 58.56 halothane 4 58.00

Disease Link Frequency Relevance Heat Unconsciousness 30 95.52 Persistent Vegetative State 18 92.96 Cognitive Disorder 28 78.88 Sleep Disorders 26 78.08 Amnesia 2 63.92 Pain 4 63.16 Alcohol Intoxication 2 56.32 Paralysis 2 22.04 Syndrome 14 18.76 Coma 24 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

All images were obtained with a Siemens MAGNETOM Tim Trio 3.0T Scanner (Erlangen, Germany) and a Siemens 12 channel Head Matrix Coil.

Gene_expression (obtained) of Trio in Head

1) Confidence 0.23 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886908 Disease Relevance 0 Pain Relevance 0

When comparing non-invasive functional neuroimaging methods (e.g. fMRI) and non-invasive functional interference techniques (e.g.

Gene_expression (techniques) of functional interference

2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0.13 Pain Relevance 0.34

When comparing non-invasive functional neuroimaging methods (e.g. fMRI) and non-invasive functional interference techniques (e.g.

Gene_expression (methods) of functional neuroimaging

3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0.13 Pain Relevance 0.32

These effects overlapped spatially with GCM functional connectivity analysis referenced to the stimulated PPC.

Gene_expression (analysis) of functional connectivity

4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789405 Disease Relevance 0 Pain Relevance 0.38

PET H2O15 activation studies on auditory processing in patients with DOC using psychophysiological interaction analyses (Friston et al., 1997), showed a higher functional connectivity between auditory sensory cortex and a widespread network of “higher-order” frontotemporoparietal areas in normal volunteers (Laureys et al., 2000a, 2002) and in patients in a minimally conscious state (Boly et al., 2004) as compared to patients in a vegetative/unresponsive state.

Gene_expression (connectivity) of functional in cortex associated with persistent vegetative state

5) Confidence 0.03 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC3010745 Disease Relevance 0.51 Pain Relevance 0.17

At higher even doses of the anesthetic, functional connectivity was virtually absent.

Neg (absent) Gene_expression (connectivity) of functional

6) Confidence 0.03 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC3010745 Disease Relevance 0.43 Pain Relevance 0.29

General Comments

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