INT28923

Context Info Confidence 0.58 First Reported 1989 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 8 Total Number 9 Disease Relevance 4.94 Pain Relevance 3.11

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha) carbohydrate metabolic process (Ldha) cytoplasm (Ldha)

Anatomy Link Frequency lung 2 blood 1 plasma 1 erythrocytes 1 bile 1 Ldha (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 27 98.88 ischemia 14 98.00 Enkephalin 10 97.18 Bile 2 95.84 depression 4 90.08 anesthesia 2 88.72 Inflammation 22 87.52 Eae 1 60.28 cINOD 1 59.28 corticosteroid 2 56.72

Disease Link Frequency Relevance Heat Lung Injury 2 99.60 Cancer 3 99.56 Necrosis 5 99.32 Weight Loss 10 98.98 Heat Stress Disorders 10 98.92 Pressure And Volume Under Development 1 98.68 Reperfusion Injury 6 98.38 Cv Unclassified Under Development 13 98.00 Infection 42 97.96 Death 15 97.80

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At high concentrations of acetaminophen (2-10 mM), pathologic effects were detected, including loss of lactate dehydrogenase from cells, disruption of cell-cell aggregation, cell death, and distinctive alterations in cell morphology, as demonstrated by light and electron microscopic examination.

Negative_regulation (loss) of lactate dehydrogenase associated with paracetamol and death

1) Confidence 0.58 Published 1993 Journal Exp. Mol. Pathol. Section Abstract Doc Link 8495715 Disease Relevance 0.36 Pain Relevance 0.56

Injection of 50 mg alpha-toc/kg significantly decreased the number of neutrophils in airspaces and prevented lung injury, monitored both as decreased lactate dehydrogenase activity in airways and reduced lung edema when compared with animals treated with plain liposomes.

Negative_regulation (decreased) of lactate dehydrogenase in lung associated with lung injury and pressure and volume under development

2) Confidence 0.53 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12540487 Disease Relevance 0.54 Pain Relevance 0.19

The LNK and ET treatment inhibited only male mouse liver aldehyde dehydrogenase in both cytoplasmic and mitochondrial preparations concomitant with reduction of plasma but not heart LDH1 isoenzyme from corresponding controls.

Negative_regulation (reduction) of LDH1 in plasma associated with enkephalin

3) Confidence 0.40 Published 1989 Journal Physiol. Behav. Section Abstract Doc Link 2813553 Disease Relevance 0.33 Pain Relevance 0.97

When Osbeckia extract (500 micrograms/ml) was added to the incubation medium at the same time as 2,6-diMeNAPQI significant changes in cell viability (78.4 +/- 3.3 versus 47.2 +/- 5.8% of control, p < 0.001), cell reduced glutathione (GSH) level (35.0 +/- 3.1 versus 23.8 +/- 1.5%, p = 0.009), and reduced release of lactate dehydrogenase (129.9 +/- 6.6 versus 224.6 +/- 12.1%, p < 0.001) were demonstrated after 1 h incubation as compared with 2,6-diMeNAPQI alone. 4.

Negative_regulation (reduced) of lactate dehydrogenase

4) Confidence 0.32 Published 1995 Journal Xenobiotica Section Abstract Doc Link 8553682 Disease Relevance 0.19 Pain Relevance 0.42

The hepatoprotective effect of the shark bile salt 5beta-scymnol has been studied in the model of acute hepatotoxicity induced by administration of acetaminophen (APAP, paracetamol). 5beta-Scymnol at doses of 20, 35, and 70 mg/kg intraperitoneally (ip) decreased significantly the serum activity of alanine aminotransferase, sorbitol dehydrogenase, and lactate dehydrogenase (p < 0.05) caused by APAP treatment (350 mg/kg ip) alone.

Negative_regulation (decreased) of lactate dehydrogenase in bile associated with paracetamol, bile and hepatotoxicity

5) Confidence 0.21 Published 1996 Journal Fundam Appl Toxicol Section Abstract Doc Link 8812214 Disease Relevance 0.42 Pain Relevance 0.36

Four hours after the acetaminophen injection, mice were decapitated and their blood was taken to determine serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and tumor necrosis factor-alpha (TNF-alpha) levels.

Spec (determine) Negative_regulation (determine) of lactate dehydrogenase in blood associated with necrosis, paracetamol and cancer

6) Confidence 0.18 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16822497 Disease Relevance 0.46 Pain Relevance 0.42

A significant protection against ischemia-reperfusion injury was observed 48 h after HS as demonstrated by: 1) reduction in infarct size; 2) decrease in leakage of lactate dehydrogenase; and 3) enhanced postischemic ventricular contractile function.

Negative_regulation (decrease) of lactate dehydrogenase associated with reperfusion injury, ischemia and heat stress disorders

7) Confidence 0.14 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.13 Pain Relevance 0.18

In mice treated 9x with the PCN, the protection against a subsequent primary influenza virus infection was characterized by a significantly greater reduction in viral burdens by day 7 post-infection (Figure 3A), and by the absence of any weight loss (Figure 3B), and lung damage, as indicated by the decreased levels of albumin (Figure 3C) and lactate dehydrogenase (LDH) (Figure 3D) recovered from the broncho-alveolar lavage fluid (BALF) [11], [12].

Negative_regulation (decreased) of lactate dehydrogenase in lung associated with weight loss, influenza virus infection and infection

8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.52 Pain Relevance 0

In this small study, mean lactate dehydrogenase (LDH) levels decreased significantly over the course of the study; the percentage of PNH erythrocytes increased significantly; transfusion rates declined; and the occurrence of hemoglobinuria subsided dramatically.

Negative_regulation (decreased) of lactate dehydrogenase in erythrocytes associated with paroxysmal nocturnal hemoglobinuria and hemoglobinuria

9) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.99 Pain Relevance 0

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