INT289275

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Piga) endoplasmic reticulum (Piga) biosynthetic process (Piga)
Anatomy Link Frequency
bone marrow 2
Piga (Mus musculus)
Pain Link Frequency Relevance Heat
cva 7 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 14 97.78 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 97 89.00 High High
Stress 1 82.56 Quite High
Apoptosis 2 76.16 Quite High
Syndrome 1 43.04 Quite Low
Hemolysis 29 7.52 Low Low
Thrombosis 25 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low
Fatigue 5 5.00 Very Low Very Low Very Low
Chronic Renal Failure 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inoue et al proposed a two stage model for the disease whereby clonal selection and clonal expansion occur by two separate events.32 In this model, clonal selection relates to the PIG-A mutation, occurring in the setting of bone marrow failure with clonal expansion being due to a separate mutation within the PIG-A mutated HSC which confers a proliferative advantage.
Positive_regulation (relates) of Gene_expression (mutation) of PIG-A in bone marrow associated with disease
1) Confidence 0.49 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789686 Disease Relevance 0.85 Pain Relevance 0

General Comments

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