INT289493

Context Info Confidence 0.03 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.61 Pain Relevance 0

molecular_function (Narfl) cellular_component (Narfl)

Anatomy Link Frequency eyes 2 Narfl (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 18 5.00 ischemia 9 5.00 midbrain 3 5.00 ketamine 3 5.00 glial activation 3 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Ocular Hypertension 309 100.00 Optic Nerve Injuries 12 82.92 Glaucoma 39 59.04 Injury 36 46.96 Ganglion Cysts 33 5.00 Death 27 5.00 Optic Disorders 18 5.00 Disease 12 5.00 Cv Unclassified Under Development 9 5.00 Retina Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our measurement of ERG responses using a series of flashes with varying light intensity allowed us to evaluate the functional changes longitudinally; the results showed that the STR was severely affected shortly after the rise in IOP, and this alteration was maintained throughout the longest survival interval examined, 8 weeks, thus providing additional functional evidence of the loss of RGCs in this model.

Regulation (affected) of IOP associated with ocular hypertension

1) Confidence 0.03 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.56 Pain Relevance 0

There was some variability among maximum IOP values in the lasered eyes within individuals and within groups processed at different survival intervals, but the results were generally consistent.

Regulation (values) of IOP in eyes associated with ocular hypertension

2) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.41 Pain Relevance 0

The statistical analysis showed that within animal groups, IOP values were comparable in the lasered eyes at 24 h (Kruskal–Wallis test, p=0.0891) and 48 h (Kruskal–Wallis test, p=0.9024) after lasering.

Regulation (values) of IOP in eyes associated with ocular hypertension

3) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.64 Pain Relevance 0

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