INT289505

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.04
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ezr) cytosol (Ezr) nucleolus (Ezr)
plasma membrane (Ezr) cytoskeleton (Ezr) intracellular (Ezr)
Anatomy Link Frequency
epithelium 1
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 33 99.96 Very High Very High Very High
Spinal cord 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 33 99.96 Very High Very High Very High
Targeted Disruption 2 99.86 Very High Very High Very High
Adenocarcinoma 81 98.80 Very High Very High Very High
Disease 6 97.52 Very High Very High Very High
Pancreatic Cancer 66 97.20 Very High Very High Very High
Metastasis 123 96.84 Very High Very High Very High
Dyskinesias 1 91.40 High High
Nicotine Addiction 108 83.64 Quite High
Cancer 81 74.60 Quite High
Pancreatic Ductal Carcinoma 9 61.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pancreatic precancerous lesions, such as PanINs and chronic pancreatitis, blocking ezrin function may have therapeutic effects that prevent these two diseases from progressing to pancreatic cancer.


Negative_regulation (blocking) of ezrin associated with pancreatic cancer, disease and chronic pancreatitis
1) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.09 Pain Relevance 0.18
These results indicate that blocking ezrin function may represent a novel and effective strategy for preventing pancreatic cancer progression, invasion and metastasis.
Negative_regulation (blocking) of ezrin associated with pancreatic cancer and metastasis
2) Confidence 0.43 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.16 Pain Relevance 0.17
Establishment of ezrin overexpression monoclones and silencing of the ezrin gene in MiaPaCa-2 cells
Negative_regulation (Establishment) of ezrin
3) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 0.34 Pain Relevance 0
In ezrin knockout mice, loss of ezrin has been reported to be associated with substantial reduction in length of the apical micro-villi of the retinal epithelium [59], but its role in respiratory epithelium is not yet known.
Negative_regulation (loss) of ezrin in epithelium associated with targeted disruption
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790614 Disease Relevance 0.45 Pain Relevance 0

General Comments

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