INT289767

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.05

cell differentiation (Pgf) extracellular space (Pgf) signal transduction (Ptgfr) extracellular region (Pgf) plasma membrane (Ptgfr) signal transducer activity (Ptgfr)

Ptgfr (Mus musculus) Pgf (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 11 97.84 Kinase C 11 5.00 adenocard 2 5.00 fibrosis 1 5.00 endometriosis 1 5.00 imagery 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Endometriosis (extended) 6 36.16 Targeted Disruption 3 5.00 Reprotox - General 1 2 5.00 Intestinal Cancer 2 5.00 Fibrosis 1 5.00 Female Infertility 1 5.00 Alopecia 1 5.00 Pancreatitis 1 5.00 Cancer 1 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Using specific receptor antagonists and small molecule chemical inhibitors of cell signaling we dissected the signaling pathways mediating the PGF-induced augmentation of cAMP in cells treated with the combination of ligands and have shown that the PGF-enhancement of cAMP observed in FPEP2 cells treated with Butaprost and PGF was induced via the FP receptor-G?

FP receptor Positive_regulation (induced) of Positive_regulation (enhancement) of PGF associated with antagonist

1) Confidence 0.03 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.05

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