INT289775

From wiki-pain
Revision as of 11:04, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 5.69
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
cartilage 4
ligament 1
tendon 1
skeletal muscle 1
Comp (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 345 98.08 Very High Very High Very High
Inflammation 138 93.92 High High
rheumatoid arthritis 78 80.00 Quite High
cytokine 49 78.96 Quite High
agonist 86 72.84 Quite High
chemokine 24 70.16 Quite High
antagonist 11 55.00 Quite High
Inflammatory response 12 50.00 Quite Low
dexamethasone 15 5.00 Very Low Very Low Very Low
Osteoarthritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 21 99.12 Very High Very High Very High
Experimental Arthritis 147 98.08 Very High Very High Very High
Arthritis 244 96.80 Very High Very High Very High
INFLAMMATION 141 93.92 High High
Muscle Disease 87 93.48 High High
Disease 62 83.76 Quite High
Rheumatoid Arthritis 78 80.00 Quite High
Endometriosis (extended) 10 70.08 Quite High
Autoimmune Disease 31 61.96 Quite High
Stress 72 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum levels of COMP were significantly decreased in the raloxifene treated mice and mice with intact endogenous hormones compared to vehicle controls.
Negative_regulation (decreased) of COMP
1) Confidence 0.41 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009959 Disease Relevance 0.79 Pain Relevance 0.23
COMP was not decreased in the estradiol treated mice, although this group also displayed significantly less cartilage destruction.
Neg (not) Negative_regulation (decreased) of COMP in cartilage
2) Confidence 0.41 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009959 Disease Relevance 0.89 Pain Relevance 0.25
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of Comp in ligament
3) Confidence 0.37 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
Therapeutic treatment with EE decreased the serum COMP (biomarker of cartilage destruction) levels in CIA, which is in line with the protective effect of EE on cartilage destruction as measured with histopathology (Figure 4a).
Negative_regulation (decreased) of serum COMP in cartilage associated with arthritis
4) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.00 Pain Relevance 0.45
The reduced cartilage destruction was associated with a dose-dependent decrease of serum COMP levels.
Negative_regulation (decrease) of serum COMP in cartilage
5) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.81 Pain Relevance 0.62
The reductions in COMP levels were associated with prevention of cartilage destruction as evidenced by histopathological examination.
Negative_regulation (reductions) of COMP in cartilage
6) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.39 Pain Relevance 0.65
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of Comp in tendon
7) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of Comp in skeletal muscle
8) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox