INT289776

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.86 Pain Relevance 0.08

unfolded protein binding (Dnajc1) protein folding (Dnajc1) endoplasmic reticulum (Dnajc1) nucleus (Dnajc1) DNA binding (Dnajc1)

Anatomy Link Frequency Muscle 1 Dnajc1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 2 83.76 Osteoarthritis 8 5.00 Arthritis 2 5.00

Disease Link Frequency Relevance Heat Muscle Disease 58 99.98 Muscle Weakness 22 99.02 Osteoarthritis 12 90.40 Joint Instability 20 86.40 Arthralgia 2 83.76 Dwarfism 8 82.72 Osteochondrodysplasias 78 80.16 Stress 48 76.88 Sprains And Strains 28 72.80 Congenital Anomalies 6 56.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Muscle weakness in Comp T585M mice results from a mild myopathy localized to the perimysium and the MTJ

Localization (localized) of MTJ in Muscle associated with muscle disease and muscle weakness

1) Confidence 0.11 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.83 Pain Relevance 0

We have demonstrated that Comp T585M mutant mice suffer from a progressive myopathy that is specifically localized to the perimysium and the MTJ.

Localization (localized) of MTJ associated with muscle disease

2) Confidence 0.11 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 1.03 Pain Relevance 0.08

General Comments

This test has worked.