INT28985

Context Info Confidence 0.44 First Reported 1982 Last Reported 1998 Negated 2 Speculated 1 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 0.81 Pain Relevance 1.67

Anatomy Link Frequency tail 1 body 1 epi (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 6 99.80 Eae 5 99.80 anesthesia 2 98.96 lidocaine 2 91.08 agonist 4 90.40 analgesia 4 87.68 epidural 7 87.28 Clonidine 2 84.20 Catecholamine 3 81.04 local anesthetic 2 60.16

Disease Link Frequency Relevance Heat Aggression 2 96.72 Taste Disorders 1 94.92 Tinnitus 1 94.04 Convulsion 3 93.20 Nociception 2 92.60 Toxicity 1 84.84 Decompression Sickness 2 75.00 Myocardial Infarction 1 54.24 Stress 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of Pluchea indica Less root extract (PI-E) on locomotor activity and pentobarbital-induced sleep, social isolation-induced aggressive behavior, motor coordination in the rotarod test, pentylenetetrazole-induced convulsion and nociceptive responses in the tail-pinch test were examined in mice.

Spec (examined) Regulation (effects) of PI-E in tail associated with nociception, convulsion, eae and aggression

1) Confidence 0.44 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8924905 Disease Relevance 0.28 Pain Relevance 0.15

YO completely aborted the effects of Epi on net Cl flux.

Regulation (effects) of Epi

2) Confidence 0.22 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 6278952 Disease Relevance 0 Pain Relevance 0.28

Prazosin (PZ), a specific alpha 1-antagonist, did not alter the Epi dose-response curve at concentrations up to 10(-5) M.

Neg (not) Regulation (alter) of Epi associated with antagonist

3) Confidence 0.19 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 6278952 Disease Relevance 0 Pain Relevance 0.32

We studied the relationship between changes in norepinephrine (NE) and epinephrine (Epi) levels, total body spillover, and total body clearance at birth.

Regulation (changes) of Epi in body

4) Confidence 0.16 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8779844 Disease Relevance 0 Pain Relevance 0.13

He-O2 breathing did not affect concentrations of Epi, NE, cortisol, T4, T3, or serum ACE activity.

Neg (not) Regulation (affect) of Epi

5) Confidence 0.08 Published 1987 Journal Undersea Biomed Res Section Abstract Doc Link 2820102 Disease Relevance 0.14 Pain Relevance 0.10

The sensitivity of EpiTD was 100%, the specificity 96%, the negative predictive value 100%, and the positive predictive value 63%.

Regulation (sensitivity) of EpiTD

6) Confidence 0.01 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9585281 Disease Relevance 0.38 Pain Relevance 0.70

General Comments

This test has worked.