INT290377

Context Info Confidence 0.24 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.95 Pain Relevance 0.23

plasma membrane (NOD2, TLR2) cytoplasm (NOD2, TLR2) cytosol (NOD2) signal transduction (TLR2) intracellular (TLR2) enzyme binding (NOD2)

Anatomy Link Frequency bowel 2 NOD2 (Homo sapiens) TLR2 (Homo sapiens)

Pain Link Frequency Relevance Heat Crohn's disease 1 99.58 Inflammation 16 96.80 Fibrositis 97 62.40 Pain 9 43.36 spastic colon 1 18.80 chemokine 12 9.68 cytokine 12 5.00 rheumatoid arthritis 5 5.00 Catechol-O-methyltransferase 4 5.00 Catecholamine 2 5.00

Disease Link Frequency Relevance Heat Disease 12 99.58 INFLAMMATION 17 96.80 Familial Mediterranean Fever 25 92.52 Syndrome 7 89.24 Fever 3 84.44 Apoptosis 1 69.00 Fibromyalgia 97 62.40 Death 3 55.20 Pain 10 43.36 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 1 19.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This situation would be similar to the role of NOD2 in Crohn's disease, in which wild type NOD2, also a member of the NLR family [40], inhibits TLR2 (toll-like receptor-2) activation by peptidoglycan, while mutated NOD2 fails to inhibit TLR2, leading to chronic inflammation in the bowel [41].

NOD2 Negative_regulation (inhibits) of Positive_regulation (activation) of toll-like receptor-2 in bowel associated with inflammation, crohn's disease and disease

1) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.95 Pain Relevance 0.23

General Comments

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