INT290671

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.59
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3, Stat3) cytoplasm (Socs3, Stat3) cell proliferation (Stat3)
plasma membrane (Stat3) nucleus (Stat3) DNA binding (Stat3)
Socs3 (Mus musculus)
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 29 100.00 Very High Very High Very High
Inflammation 78 97.12 Very High Very High Very High
Inflammatory response 7 95.68 Very High Very High Very High
cINOD 3 19.52 Low Low
agonist 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 28 99.76 Very High Very High Very High
INFLAMMATION 87 97.12 Very High Very High Very High
Colorectal Cancer 18 94.24 High High
Skin Cancer 2 93.12 High High
Cancer 29 91.04 High High
Colitis 12 77.56 Quite High
Repression 5 49.20 Quite Low
Multiple Myeloma 1 17.48 Low Low
Toxicity 11 7.04 Low Low
Inflammatory Bowel Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOCS3 has been shown to limit the actions of both of these cytokines as well as their downstream targets STAT3 and NF?
SOCS3 Binding (targets) of STAT3 associated with cytokine
1) Confidence 0.23 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883989 Disease Relevance 1.18 Pain Relevance 0.27
SOCS3 plays an essential role as a negative inhibitor of IL-6 by interfering with STAT3 [90].
SOCS3 Binding (interfering) of STAT3
2) Confidence 0.20 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.41 Pain Relevance 0.18

General Comments

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