INT291134

Context Info Confidence 0.62 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.64 Pain Relevance 0.26

mitochondrion (PDP1) small molecule metabolic process (PDP1)

Anatomy Link Frequency plasma 1 skeletal muscle 1 PDP1 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 3 94.16 Chronic pancreatitis 35 86.92 Immobilon 3 86.72 fibrosis 20 56.24 Inflammation 13 38.00 Bile 5 5.00 anesthesia 3 5.00 lidocaine 3 5.00 alcohol 2 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Hypertension 19 100.00 Pancreatitis 57 86.92 Fibrosis 23 63.76 Insulin Resistance 12 46.28 Injury 15 42.72 Fat Necrosis 1 42.72 INFLAMMATION 13 38.72 Body Weight 22 25.04 Exocrine Pancreatic Insufficiency 2 19.72 Sprains And Strains 3 6.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

subunit and phosphorylation of site 1 and 2 of PDH-E1?

Gene_expression (subunit) of PDH

1) Confidence 0.62 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0.09

Also based on findings in rat skeletal muscle, plasma FFA is also believed to reduce PDH activity through a peroxisome proliferator–activated receptor (PPAR)-?

Gene_expression (activity) of PDH in plasma

2) Confidence 0.62 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0

Also based on findings in rat skeletal muscle, plasma FFA is also believed to reduce PDH activity through a peroxisome proliferator–activated receptor (PPAR)-?

Gene_expression (activity) of PDH in skeletal muscle

3) Confidence 0.21 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0

In the PDH rats, ?

Gene_expression (rats) of PDH associated with hypertension

4) Confidence 0.16 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC3010641 Disease Relevance 0.64 Pain Relevance 0.17

General Comments

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