INT291191

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Kdr) plasma membrane (Kdr) nucleus (Kdr)
cytoplasm (Kdr)
Anatomy Link Frequency
anterior pituitary 2
microglia 2
Kdr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 30 15.24 Low Low
imagery 51 5.00 Very Low Very Low Very Low
ischemia 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Percutaneous transluminal coronary angioplasty 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 185 99.88 Very High Very High Very High
Diabetes Mellitus 186 95.72 Very High Very High Very High
Myocardial Infarction 138 90.56 High High
Pituitary Cancer 8 80.56 Quite High
Necrosis 1 52.72 Quite High
Ventricular Remodeling 20 50.00 Quite Low
Prolactinoma 1 50.00 Quite Low
Severe Combined Immunodeficiency 1 29.52 Quite Low
Fibrosis 32 15.24 Low Low
Adenoma 1 14.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Flk-1 has been reported to be detected in the anterior pituitary cells and this finding supports the autocrine/paracrine functions
Negative_regulation (detected) of Gene_expression (Expression) of Flk-1 in anterior pituitary
1) Confidence 0.24 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.66 Pain Relevance 0
Multiple cells in the brain (possibly microglia) near the tumors also exhibited high expression of VEGFR2 and VEGFR3.
Negative_regulation (exhibited) of Gene_expression (expression) of VEGFR2 in microglia associated with cancer
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 1.61 Pain Relevance 0
Similarly, there was a significant reduction in the expression of VEGF (2.5-fold) and Flk-1 (2.5-fold) in the DLZMI group compared with the CLZMI group (Fig. 4C and D).
Negative_regulation (reduction) of Gene_expression (expression) of Flk-1
3) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.09 Pain Relevance 0
We observed a significant reduction in the expression of VEGF (1.75-fold) and Flk-1 (7.1-fold) 4 days after the surgical procedure in the DS-operated animals compared with the CS-operated animals (Fig. 4A and B).
Negative_regulation (reduction) of Gene_expression (expression) of Flk-1
4) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.10 Pain Relevance 0

General Comments

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