INT291205

Context Info Confidence 0.59 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.83 Pain Relevance 0.18

signal transduction (Map3k8) cell cycle (Map3k8) kinase activity (Map3k8) cytoplasm (Map3k8)

Anatomy Link Frequency adipose tissue 1 Map3k8 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 39 100.00 Inflammation 26 96.52 Inflammatory stimuli 5 9.48 Inflammatory mediators 2 5.00 tolerance 1 5.00 anesthesia 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Obesity 106 96.68 INFLAMMATION 33 96.52 Diabetes Mellitus 8 86.68 Cancer 5 50.00 Necrosis 3 50.00 Insulin Resistance 10 22.44 Hypertension 1 5.00 Targeted Disruption 1 5.00 Impaired Glucose Tolerance 1 5.00 Dislocations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The implication of Tpl2 in cytokine-induced lipolysis and IRS-1 serine phosphorylation suggested that abnormal activation and/or expression of Tpl2 could be involved in adipose tissue dysfunction in obesity.

Phosphorylation (phosphorylation) of Tpl2 in adipose tissue associated with obesity and cytokine

1) Confidence 0.59 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.83 Pain Relevance 0.18

General Comments

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