INT291239

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0.11

cell differentiation (Mdk) signal transduction (Map3k8) extracellular region (Mdk) cell cycle (Map3k8) kinase activity (Map3k8) cytoplasm (Map3k8)

Anatomy Link Frequency 3T3-L1 1 adipocytes 1 Map3k8 (Mus musculus) Mdk (Mus musculus)

Pain Link Frequency Relevance Heat Inflammatory stimuli 5 92.68 cytokine 39 72.16 Inflammatory mediators 2 57.60 Inflammation 26 30.52 tolerance 1 5.00 anesthesia 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Obesity 106 99.54 INFLAMMATION 33 92.36 Cancer 5 50.00 Necrosis 3 50.00 Insulin Resistance 10 5.00 Diabetes Mellitus 8 5.00 Hypertension 1 5.00 Targeted Disruption 1 5.00 Impaired Glucose Tolerance 1 5.00 Dislocations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In both 3T3-L1 and human adipocytes, we demonstrated that Tpl2 was involved in MEK/ERK1/2 activation in response to IL-1?

Tpl2 Regulation (involved) of in adipocytes Positive_regulation (activation) of MEK in 3T3-L1 associated with obesity

1) Confidence 0.08 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.53 Pain Relevance 0.11

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