INT291252

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.64 Pain Relevance 0.14

cytoplasm (Map3k8, MAPK1) signal transduction (Map3k8, MAPK1) cell cycle (Map3k8, MAPK1) nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)

Map3k8 (Mus musculus) MAPK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 26 82.24 cytokine 39 66.28 Inflammatory stimuli 5 5.00 Inflammatory mediators 2 5.00 tolerance 1 5.00 anesthesia 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Obesity 106 87.56 INFLAMMATION 33 82.24 Diabetes Mellitus 8 52.32 Cancer 5 50.00 Necrosis 3 50.00 Insulin Resistance 10 5.00 Hypertension 1 5.00 Targeted Disruption 1 5.00 Impaired Glucose Tolerance 1 5.00 Dislocations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the results presented in Fig. 7E, and the observation that Tpl2 overexpression increases ERK1/2 activity (32), suggest that Tpl2 expression could be rate-limiting for the activation of ERK pathway.

Gene_expression (overexpression) of Tpl2 Positive_regulation (increases) of ERK1/2

1) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.64 Pain Relevance 0.14

General Comments

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