INT291715

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DR1, Rxra) DNA binding (DR1, Rxra) transcription factor binding (DR1, Rxra)
intracellular (DR1) enzyme binding (Rxra)
DR1 (Homo sapiens)
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 28 5.00 Very Low Very Low Very Low
Bladder Cancer 4 5.00 Very Low Very Low Very Low
Embryonic Lethality 4 5.00 Very Low Very Low Very Low
Prostatic Intraepithelial Neoplasia 4 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Confusion 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Lifespan 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the level of DNA binding, most RXR heterodimers bind selectively to the well-known “DR1 to 5” DNA response elements.
DR1 Binding (bind) of RXR
1) Confidence 0.09 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
Nevertheless, the specificity of RXR/PPAR heterodimer to PPRE does not necessarily preclude DNA binding by other RXR heterodimers that also recognize the DR1 element.

3.

DR1 Binding (recognize) of RXR
2) Confidence 0.08 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
, resembling the organization of RXR/RAR on DR1 [25] (Figure 1).
DR1 Binding (organization) of RXR
3) Confidence 0.07 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
A well-known example is that the RXR homodimer and several other RXR heterodimers can recognize and bind to the DR1 element [29].
DR1 Binding (bind) of RXR
4) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

General Comments

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