INT291788

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ALDOA) lyase activity (ALDOA) GTPase activity (Gnat3)
carbohydrate metabolic process (ALDOA) cytoplasm (Gnat3) signal transducer activity (Gnat3)
ALDOA (Homo sapiens)
Gnat3 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 14 89.48 High High
Potency 3 88.00 High High
Angina 6 51.56 Quite High
alcohol 10 29.60 Quite Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
noradrenaline 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 3 84.72 Quite High
Increased Venous Pressure Under Development 5 79.64 Quite High
Targeted Disruption 11 70.48 Quite High
Cardiovascular Disease 7 66.16 Quite High
Cv General 3 Under Development 5 51.56 Quite High
Myocardial Infarction 11 30.48 Quite Low
Toxicity 9 27.60 Quite Low
Stress 23 14.72 Low Low
Cv Unclassified Under Development 15 5.00 Very Low Very Low Very Low
Heart Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alda-1 caused slight inhibition of GTN denitration and did not increase GTN-induced sGC activation in the presence of either variant.
Alda-1 Neg (not) Positive_regulation (increase) of GTN
1) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0.04
Since Alda-1 activates both the dehydrogenase activity and esterase activity of ALDH2,9,68 Beretta et al. evaluated the effect of Alda-1 on bioactivation of nitroglyercin.69 Surprisingly, Alda-1 failed to increase GTN denitration and bioactivation in these assays using either the ALDH2 wild-type and ALDH2*2 recombinant enzyme in vitro.
Alda-1 Neg (failed) Positive_regulation (increase) of GTN
2) Confidence 0.01 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.52 Pain Relevance 0.14

General Comments

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