INT291800

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 0.57
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NEU2) small molecule metabolic process (NEU2) hydrolase activity, acting on glycosyl bonds (NEU2)
cytoplasm (NEU2)
Anatomy Link Frequency
internal 1
NEU2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 81 99.54 Very High Very High Very High
Inflammation 52 95.12 Very High Very High Very High
Cannabinoid 64 86.80 High High
Pain 32 86.76 High High
imagery 56 82.76 Quite High
chemokine 8 79.12 Quite High
Glutamate 8 77.84 Quite High
Serotonin 5 73.80 Quite High
agonist 1 72.60 Quite High
Potency 8 59.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 52 95.12 Very High Very High Very High
Pain 32 86.76 High High
Cv General 3 Under Development 54 59.16 Quite High
Spasticity 8 55.12 Quite High
Coronary Vasospasm 7 42.16 Quite Low
Acute Monocytic Leukemia 8 40.28 Quite Low
Spontaneous Remission 1 22.20 Low Low
Atherosclerosis 9 19.44 Low Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is also well known that the relationship between elevation of cytosolic Ca2+ concentration and the degree of developed tension varies depending on the situation.61) The Ca2+-tension relationship changes during the time course of the contraction, in which the sustained phase of the contraction is maintained by a relatively lower level of cytosolic Ca2+.
Positive_regulation (elevation) of cytosolic
1) Confidence 0.01 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 0.17 Pain Relevance 0.13
In conclusion, we show that extracts from Echinacea induce transient increases of cytosolic Ca2+ levels when applied to HEK293 cells, and that this increase can be attributed to a subset of lipohilic Echinacea constituents.
Positive_regulation (increases) of cytosolic
2) Confidence 0.00 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.12
HPLC fractionation reveals six distinct lipophilic fractions that induce this transient increase in cytosolic Ca2+.
Positive_regulation (increase) of cytosolic
3) Confidence 0.00 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.12
After Ca2+-containing medium is introduced, a sustained increase in cytosolic Ca2+ is observed for both treatments (Figure 6A, 6B).
Positive_regulation (increase) of cytosolic
4) Confidence 0.00 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Furthermore, the PLC pathway may play a role in this release, as suggested by the observation that the Echinacea-evoked increase in cytosolic Ca2+ is blocked by the PLC antagonist U-73122, but not by its inactive analog (U-73343).
Positive_regulation (increase) of cytosolic associated with antagonist
5) Confidence 0.00 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.14 Pain Relevance 0.31
We tested for the possible involvement of the IP3 receptor in the Echinacea-induction of intracellular Ca2+ release by evaluating the effect of 2-aminoethoxydiphenyl borate (2-APB), an IP3 receptor antagonist, on Echinacea-induced cytosolic Ca2+ increase.
Positive_regulation (increase) of cytosolic associated with antagonist
6) Confidence 0.00 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.05
Our data indicate that the source of the initial transient increase in cytosolic calcium levels that are induced by Echinacea-extracts is from internal stores, indicative of a metabotropic response.
Positive_regulation (induced) of cytosolic in internal
7) Confidence 0.00 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.10 Pain Relevance 0.11
Based on these data, we reveal an Echinacea-induced stimulation of an increase in cytosolic Ca2+ that is not-CB2-dependent, and is not associated with the major alkamides of E. purpurea.
Positive_regulation (increase) of cytosolic
8) Confidence 0.00 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.17 Pain Relevance 0.26
A rapid transient increase in cytosolic Ca2+ levels occurs when E. purpurea extracts are applied to HEK293 cells.
Positive_regulation (increase) of cytosolic
9) Confidence 0.00 Published 2010 Journal BMC Complement Altern Med Section Abstract Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.16

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