INT2919

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 47
Total Number 47
Disease Relevance 23.48
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F8) oxidoreductase activity (F8) extracellular region (F8)
cell adhesion (F8)
Anatomy Link Frequency
blood 6
platelet 3
iliopsoas 2
lumbar region 1
muscle 1
F8 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 3 100.00 Very High Very High Very High
Pain 29 99.80 Very High Very High Very High
cva 71 99.76 Very High Very High Very High
Paracetamol 8 99.40 Very High Very High Very High
addiction 2 99.22 Very High Very High Very High
lumbar region 1 99.08 Very High Very High Very High
Analgesic 3 99.00 Very High Very High Very High
epidural 2 98.48 Very High Very High Very High
imagery 1 97.72 Very High Very High Very High
corticosteroid 14 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 3 100.00 Very High Very High Very High
Disease 28 99.96 Very High Very High Very High
Factor Viii Deficiency 9 99.96 Very High Very High Very High
Systemic Lupus Erythematosus 2 99.92 Very High Very High Very High
Coagulation Disorder 159 99.84 Very High Very High Very High
Hemorrhage 159 99.80 Very High Very High Very High
Pain 15 99.80 Very High Very High Very High
Factor Ix Deficiency 1 99.80 Very High Very High Very High
Thrombophilia 4 99.62 Very High Very High Very High
Cv General 3 Under Development 16 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of acute bleeding events is unsatisfactory in patients with haemophilia and high-titre factor VIII (FVIII) inhibitors.
Negative_regulation (inhibitors) of FVIII associated with coagulation disorder and hemorrhage
1) Confidence 0.59 Published 2007 Journal Haemophilia Section Abstract Doc Link 17212730 Disease Relevance 0.27 Pain Relevance 0.09
However, acetaminophen-treated mice demonstrated markedly reduced fVIII activity, contrary to the observation in human FHF. von Willebrand factor antigen levels were only mildly reduced, suggesting that the decrease in fVIII is not secondary to loss of von Willebrand factor.
Negative_regulation (reduced) of fVIII associated with paracetamol and acute liver failure
2) Confidence 0.58 Published 2003 Journal Blood Section Abstract Doc Link 12730105 Disease Relevance 0.77 Pain Relevance 0.36
Of these 19 patients with haemophilia A who had iliopsoas haemorrhage, seven (36.8%) had an inhibitor to factor VIII (FVIII), and accounted for one-half of the bleeding episodes.
Negative_regulation (inhibitor) of FVIII in iliopsoas associated with coagulation disorder, hemorrhage and cva
3) Confidence 0.56 Published 2003 Journal Haemophilia Section Abstract Doc Link 14750939 Disease Relevance 1.52 Pain Relevance 0.33
Treatment of acute bleeding events is unsatisfactory in patients with haemophilia and high-titre factor VIII (FVIII) inhibitors.
Negative_regulation (inhibitors) of factor VIII associated with coagulation disorder and hemorrhage
4) Confidence 0.51 Published 2007 Journal Haemophilia Section Abstract Doc Link 17212730 Disease Relevance 0.27 Pain Relevance 0.09
Decreased factor VIII levels during acetaminophen-induced murine fulminant hepatic failure.
Negative_regulation (Decreased) of factor VIII associated with paracetamol and acute liver failure
5) Confidence 0.51 Published 2003 Journal Blood Section Title Doc Link 12730105 Disease Relevance 0.75 Pain Relevance 0.33
In moderate doses of 20 mL/kg (1.2 g/kg), hydroxyethyl starch (HES) 6% decreases factor VIII:C activity.
Negative_regulation (decreases) of factor VIII
6) Confidence 0.49 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8831325 Disease Relevance 0.07 Pain Relevance 0.07
After HES administration, factor VIII:C levels decreased significantly, to 69% of baseline, in both groups.
Negative_regulation (decreased) of factor VIII
7) Confidence 0.49 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8831325 Disease Relevance 0.09 Pain Relevance 0.09
Of these 19 patients with haemophilia A who had iliopsoas haemorrhage, seven (36.8%) had an inhibitor to factor VIII (FVIII), and accounted for one-half of the bleeding episodes.
Negative_regulation (inhibitor) of factor VIII in iliopsoas associated with coagulation disorder, hemorrhage and cva
8) Confidence 0.49 Published 2003 Journal Haemophilia Section Abstract Doc Link 14750939 Disease Relevance 1.52 Pain Relevance 0.33
Mice deficient in factor VIII coagulant activity were trained to ambulate on a rotating rod then injured three times at weekly intervals.
Negative_regulation (deficient) of factor VIII
9) Confidence 0.43 Published 2008 Journal Haemophilia Section Abstract Doc Link 18184259 Disease Relevance 1.03 Pain Relevance 0.16
In this paper, we review the pathogenesis of HS and present experimental data from mice deficient in factor VIII or IX activity in order to clarify the pathways by which blood in the joint space results in arthropathy.
Negative_regulation (deficient) of factor VIII in blood associated with synovitis and arthropathy
10) Confidence 0.43 Published 2008 Journal Semin. Hematol. Section Abstract Doc Link 18544426 Disease Relevance 1.48 Pain Relevance 0.27
Examinations revealed a marked depression of factor VIII activity (5%) and the presence of 31 Bethesda units/ml factor VIII inhibiting activity.
Negative_regulation (depression) of factor VIII associated with depression
11) Confidence 0.41 Published 1993 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8329575 Disease Relevance 0.50 Pain Relevance 0.14
Examinations revealed a marked depression of factor VIII activity (5%) and the presence of 31 Bethesda units/ml factor VIII inhibiting activity.
Negative_regulation (inhibiting) of factor VIII associated with depression
12) Confidence 0.41 Published 1993 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8329575 Disease Relevance 0.50 Pain Relevance 0.14
We report a 74-year-old Japanese woman who had bleeding due to a factor VIII inhibitor in the absence of diseases known to be associated with its development.
Negative_regulation (inhibitor) of factor VIII associated with hemorrhage and disease
13) Confidence 0.41 Published 1993 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8329575 Disease Relevance 0.37 Pain Relevance 0.13
In order to determine whether short-term corticosteroid therapy enhances resolution of the signs and symptoms of acute haemarthrosis, we performed a randomized, double-blind, placebo-controlled study in children with FVIII deficiency and high-titre inhibitors receiving Factor Eight Inhibitor Bypass Activity (FEIBA) for acute haemorrhagic events.
Negative_regulation (deficiency) of FVIII associated with corticosteroid
14) Confidence 0.38 Published 2007 Journal Haemophilia Section Abstract Doc Link 17212730 Disease Relevance 0.31 Pain Relevance 0.12
Factor VIII inhibitor in insulin-dependent diabetes mellitus.
Negative_regulation (inhibitor) of Factor VIII associated with diabetes mellitus
15) Confidence 0.36 Published 1989 Journal Am. J. Hematol. Section Title Doc Link 2492761 Disease Relevance 0.38 Pain Relevance 0.09
The authors describe a patient with von Willebrand's disease in whom pregnancy itself improved factor VIII activity, enabling performance of an epidural block for labor and delivery.
Negative_regulation (improved) of factor VIII associated with epidural and disease
16) Confidence 0.36 Published 1989 Journal Reg Anesth Section Abstract Doc Link 2487672 Disease Relevance 0.27 Pain Relevance 0.16
Patient 2 had von Willebrand disease (decreased factor VIII antigen and quantitative ristocetin cofactor activity).
Negative_regulation (decreased) of factor VIII associated with disease
17) Confidence 0.36 Published 1990 Journal Pediatrics Section Abstract Doc Link 2371098 Disease Relevance 0.68 Pain Relevance 0.09
Thus, early post transplant events during the initial two weeks are critically affected by the lack of factor VIII in the recipient mice.
Negative_regulation (lack) of factor VIII
18) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791444 Disease Relevance 0.36 Pain Relevance 0
The patient had a long history of coagulopathy due to factor VIII deficiency and pain in the right lumbar region.
Negative_regulation (deficiency) of factor VIII in lumbar region associated with pain, coagulation disorder and lumbar region
19) Confidence 0.36 Published 2002 Journal Eur. J. Clin. Microbiol. Infect. Dis. Section Abstract Doc Link 12373503 Disease Relevance 0.60 Pain Relevance 0.15
The present report describes the application of self-regulation techniques (progressive muscle relaxation, meditative breathing, and guided imagery) to the management of bleeding and arthritic pain and analgesic dependence in a 9-year-old hemophilic child with factor VIII inhibitor.
Negative_regulation (inhibitor) of factor VIII in muscle associated with addiction, pain, analgesic, hemorrhage, imagery and arthritis
20) Confidence 0.36 Published 1981 Journal Pain Section Abstract Doc Link 6795574 Disease Relevance 0.47 Pain Relevance 0.68

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