INT292154

Context Info Confidence 0.01 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.97 Pain Relevance 0.27

nucleus (TNIP1, HIVEP1) intracellular (TNIP1, HIVEP1) cytoplasm (TNIP1, HIVEP1) DNA binding (HIVEP1) translation (TNIP1)

Anatomy Link Frequency macrophages 1 TNIP1 (Homo sapiens) HIVEP1 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 2 98.16 cytokine 12 97.40 Inflammation 4 5.00 Central nervous system 2 5.00 Migraine 1 5.00 cINOD 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 141 100.00 Infection 11 99.08 Cancer 10 5.00 Dementia 9 5.00 Disease 9 5.00 INFLAMMATION 5 5.00 Immunodeficiency 4 5.00 Death 3 5.00 Necrosis 3 5.00 Disease Progression 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The HIV-1 Nef protein induces HIV-infected macrophages to secrete at least two chemokines, MIP1?

HIV-1 Nef protein Positive_regulation (induces) of HIV in macrophages associated with chemokine and acquired immune deficiency syndrome or hiv infection

1) Confidence 0.01 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.97 Pain Relevance 0.27

General Comments

This test has worked.